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KMID : 0869620080250010021
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Journal of Korean Society of Hospital Pharmacists
2008 Volume.25 No. 1 p.21 ~ p.26
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Multidose Use of Heparin and Lidocaine Vials: a Study in Stability and Sterility
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Kim Bo-Ri
Oh Eun-Sook
Lee Jung-Sun
Hwangbo Shin-Yi
Park Jung-Jun
Tak Kyung-Kuk
Kim Ki-Hwan
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Abstract
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Heparin and lidocaine in Kangnam St. Mary’s hospital are single-dose vials, but these are used as multi-dose vial when the dosage is low. There was no study about the stability of multi-dose use, so we studied about stability and sterility of multi-dose use of heparin and lidociane. Heparin inj 1,000IU/ml and 5,000IU/ml vials were stored at room temperature, under refrigeration, light protection and room light. We checked contents, external appearance and pH for the stability of heparin and the sterility was determined by checking the microbial growth at room temperature and under refrigeration at initial, 3rd, 7th, 15th day. The samples of lidocaine 2% inj were collected in room temperature and under refrigeration to assess the stability and sterility of lidocaine and were checked contents and microbial growth. In result, heparin 1,000IU/ml, 5,000IU/ml and lidocaine did not change significantly for 15days and no microbial growth was noted in all conditions. Although both heparin and lidocaine were stable in 15days, this study has limitations: the small number of samples and difference of environment between laboratory and ward. More study about multi-dose use of injectable drugs is needed.
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KEYWORD
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heparin, lidocaine, stability, sterility, multidose use
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